Alzheimer’s disease (AD), the leading cause of dementia in the aging population, is characterized by the presence of amyloid-β plaques, hyperphosphorylated tau protein and extensive neuronal loss. In this collaborative research with scientists at Rush University, RNS60 treatment of a transgenic mouse model of AD (5XFAD) suppressed neuronal death, attenuated Tau phosphorylation, inhibited neuroinflammation, and reduced the burden of amyloid-β in the hippocampus. Most importantly, RNS60 treatment protected memory and learning in 5XFAD transgenic mouse model. Therefore, RNS60 may be a promising pharmaceutical candidate for further testing as a treatment of AD.

Link to the paper: A Physically-Modified Saline Suppresses Neuronal Apoptosis, Attenuates Tau Phosphorylation and Protects Memory in an Animal Model of Alzheimer’s Disease (plos.org)