Neuronal plasticity is the ability of the brain to change or repair itself, structurally and functionally. Neuronal plasticity decreases with old age and in patients with neurodegenerative diseases such as Alzheimer’s disease (AD). Therefore, exploring therapeutic interventions to stimulate plasticity is an important area of research. Research at Rush University demonstrated that RNS60 stimulated morphological plasticity and synaptic transmission in mouse hippocampal neurons. RNS60 induced expression of key plasticity related proteins (such as PSD95 and NR2A) in cultured neurons as well as in the brain of transgenic mice (5XFAD) with dementia. These results describe a novel property of RNS60 in stimulating hippocampal plasticity, which may help to develop new therapeutic approaches for AD and other dementias.