The decline of mitochondrial number and function is associated with many neurological diseases and aging, and represents an important therapeutic target. In this publication, scientists at the Department of Neurological Sciences at Rush University Medical Center report that RNS60 increased mitochondrial biogenesis (the mechanism of growth and division of existing mitochondria) in neuronal cells in culture and in the brain of mice challenged with the neurotoxic agent MPTP. The expression of multiple genes that are key to mitochondrial function and biogenesis (PGC1α, Tfam, Nrf1, Mcu, and Tom20) was increased by RNS60 treatment. The data also revealed details of the cellular signaling pathway activated by RNS60.

Link to the paper: Increase in Mitochondrial Biogenesis in Neuronal Cells by RNS60, a Physically-Modified Saline, via Phosphatidylinositol 3-Kinase-Mediated Upregulation of PGC1α | SpringerLink