Scientists at Rush University in Chicago published a study showing that RNS60 treatment decreased the activation of inflammatory cells (astrocytes and microglia) and reduced neuronal death in the brain of mice subjected to TBI. RNS60 treatment also reduced vascular damage, maintained or improved blood-brain barrier and decreased the size of lesion in the brain of TBI mice after injury. Most importantly, RNS60 treated mice showed significant improvements in memory, social behavior and locomotor activities while displaying reduction in depression-like behaviors. These results support the testing of RNS60 as a possible treatment for TBI.

Link to the paper: RNS60, a physically-modified saline, inhibits glial activation, suppresses neuronal apoptosis and protects memory in a mouse model of traumatic brain injury – ScienceDirect