Revalesio in the News

Sizing Individual Au Particles in Solution with Sub-Nanometer Resolution

Sean R. German, Timothy S Hurd, Henry S. White, and Tony L. Mega.
Date Published June 17, 2015

Abstract: Resistive-pulse sensing has generated considerable interest as a technique for characterizing nanoparticle suspensions. The size, charge, and shape of individual particles can be estimated from features of the resistive pulse, but the technique suffers from an inherent variability due to the stochastic nature of particles translocating through a small orifice or channel.

Phase State of Interfacial Nanobubbles

Dongjin Seo, Sean R. German, Tony L. Mega & William A. Ducker
Date Published June 2, 2015

Date Published June 2, 2015 Click here to download PDF Abstract: Interfacial nanobubbles represent an interesting state of matter: tiny bubbles decorating the interface between a solid and liquid. Yet, there is only sparse evidence supporting the idea that they are indeed gaseous. Here we present evidence that nanobubbles are composed of air rather than […]

RNS60, a charge-stabilized nanostructure saline alters Xenopus Laevis oocyte biophysical membrane properties by enhancing mitochondrial ATP production

Soonwook Choi, Eunah Yu, Duk-Soo Kim, Mutsuyuki Sugimori & Rodolfo R. Llinas
Date Published January 7, 2015

Date: January, 2015 Click here to download the PDF Abstract: We have examined the effects of RNS60, a 0.9% saline containing chargestabilized oxygen nanobubble-based structures. RNS60 is generated by subjecting normal saline to Taylor–Couette–Poiseuille (TCP) flow under elevated oxygen pressure. This study, implemented in Xenopus laevis oocytes, addresses both the electrophysiological membrane properties and parallel biological processes in the cytoplasm. […]

Early results for treatment of inflammatory diseases promising for Tacoma-born biotech research company

Date Published December 22, 2014

Date: December 22, 2014 Article on Revalesio in the Tacoma newspaper. http://www.thenewstribune.com/2014/12/22/3534676/early-results-promising-as-a-tacoma.html. It looks like water, it feels like water and it could change the way medical science attacks disease. Quietly, slowly, a revolution continues to simmer on the east side of the Thea Foss Waterway at a Tacoma-born biotechnology research firm called Revalesio. And […]

Revalesio’s RNS60 Demonstrates Promise in Treating Alzheimer’s Disease and Other Dementias

Multiple published research studies outline the potential for RNS60 to effectively treat Alzheimer’s disease by protecting neuronal function and restoring neuronal plasticity
Date Published October 20, 2014

Date: October 20, 2014 Tacoma, WA – Revalesio Corporation and Rush University Medical Center’s Department of Neurological Sciences published findings from two research studies that demonstrate the potential for RNS60 to treat Alzheimer’s disease and other forms of dementia by protecting neuronal function, restoring neuronal connections and promoting neuronal plasticity. RNS60 is a therapeutic saline containing […]

Revalesio Names Bert van den Bergh President

Adds Proven Industry Leadership to Accelerate RNS60 Commercialization
Date Published

Date: October 20, 2014 Tacoma, WA – Revalesio Corporation strengthened its executive leadership with the appointment of Bert van den Bergh as President. Mr. van den Bergh brings extensive industry experience to Revalesio as the company accelerates the development and commercialization of its therapeutic, RNS60. He previously spent 30 years with Eli Lilly & Company where […]

A physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of Alzheimer’s disease

Modi KK, Jana A, Ghosh S, Watson R, Pahan K. PLoS One. 2014 Aug 4;9(8)
Date Published August 14, 2014

Date: August, 2014 www.ncbi.nlm.nih.gov Abstract: Alzheimer’s disease (AD), the leading cause of dementia in the aging population, is characterized by the presence of neuritic plaques, neurofibrillary tangles and extensive neuronal apoptosis. Neuritic plaques are mainly composed of aggregates of amyloid-? (A?) protein while neurofibrillary tangles are composed of the hyperphosphorylated tau protein. Despite intense investigations, […]

Enhancement of morphological plasticity in hippocampal neurons by a physically modified saline via phosphatidylinositol-3 kinase

Roy A, Modi KK, Khasnavis S, Ghosh S, Watson R, Pahan K. PLoS One. 2014 Jul 9;9(7)
Date Published July 16, 2014

Date: July, 2014 www.ncbi.nlm.nih.gov Abstract: Increase of the density of dendritic spines and enhancement of synaptic transmission through ionotropic glutamate receptors are important events, leading to synaptic plasticity and eventually hippocampus-dependent spatial learning and memory formation. Here we have undertaken an innovative approach to upregulate hippocampal plasticity. RNS60 is a 0.9% saline solution containing charge-stabilized […]

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