Charge-Stablized Nanostructure Technology
Revalesio is developing a novel category of therapeutics for the treatment of inflammatory diseases using its proprietary charge-stabilized nanostructure (CSN) technology. Revalesio’s products are created using a patented device that generates rotational forces, cavitation, and high-energy fluid dynamics to create unique, stable nanostructures in liquids. CSNs are less than 100 nanometers in size (for reference, the width of a single strand of hair is 100,000 nanometers) and consist of a stabilized nano-sized oxygen bubble core.
RNS60 is Revalesio’s lead product candidate based upon CSN technology. RNS60 is generated by processing normal, medical-grade, isotonic saline with Revalesio’s technology. RNS60 offers a unique and groundbreaking approach to treating diseases through a combination of three key features:
- Efficacy – Pre-clinical and clinical research has demonstrated RNS60 has significant anti-inflammatory and cytoprotective activity in multiple diseases.
- Safety – RNS60 has demonstrated an excellent safety profile in multiple pre-clinical toxicology studies and clinical trials.
- Novel Mechanism of Action – CSN technology represents a new category of therapeutics that utilize a novel approach to alter cellular signaling in response to stress without crippling normal cell function.
MECHANISM OF ACTION
In contrast to traditional therapies such as biologics and some small molecules, RNS60 was not designed to target a single cellular protein. Instead, RNS60 utilizes CSNs to disrupt inflammatory signals to prevent a cascade of biochemical events that cause cell and tissue damage. RNS60 modulates the PI3K-Akt pathway, a central pathway responsible for multiple cellular functions including cellular protection from death (apoptosis) and the reduction of inflammation. In addition, RNS60 exerts a positive impact on mitochondria and bioenergetics. In summary, therapeutics containing CSNs represent a novel approach to protect cells exposed to stressful conditions and thereby prevent and treat inflammatory diseases.