RNS60 Promotes Mitochondrial Biogenesis in Neurons

A team of scientists at Rush University in Chicago published a new study demonstrating increased formation of mitochondria and increased ATP production in neuronal cells treated with RNS60. This effect was seen both in a dopaminergic neuronal cell line and in the brain of RNS60-treated mice. The authors showed that it is mediated through increased expression of PGC-1, a key gene associated with mitochondrial biogenesis. While previous studies published by other groups had shown effects of RNS60 on neuronal ATP production as well as mitochondrial function in oligodendrocytes, the current study is the first to show a direct effect on the synthesis of new mitochondria.

Mitochondria are crucial for cellular energy production and an important organelle for the regulation of cellular aging, oxidative stress, and cell death. A decrease in their number and function contributes to neurodegenerative disorders and other pathological conditions. The ability to enhance the number and function of mitochondria may be important to treat neurodegenerative diseases such as MS and ALS.

To read the full article, click here: https://link.springer.com/article/10.1007%2Fs11481-017-9771-4